http://www.frost.com/prod/servlet/subscription-homepage.pag?svcid=D753 - Technical Insights - Genetic Technology Alert en-us Technical Insights Alert This week's issue of GTN Alerts profiles the novel discovery of a gene, which can reverse angiogenesis and thus fight cancer; research findings aimed at retinal degeneration; dendrimers nanotechnology-based platform targeting treatment for life-threatening diseases; research findings highlighting gene therapeutic approach for spinal muscular atrophy; microRNAs emerging as lung cancer therapeutics; breakthrough studies generating cancer stem cells from embryonic stem cells source. This alert also highlights few prominent strategic partnerships and includes a coverage on key patents. http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-9B-00-00 Fri, 9 May 2008 00:57:38 +0100 http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-9B-00-00 Technical Insights Alert This week's issue of GTN Alert profiles articles on usage of zebrafish models for identification of potential drug candidates; promising gene therapy involving research findings, which could be eventually translated into addiction therapies; research findings highlighting the fact that vectors could deliver successful treatments; university studies focused on creating synthetic cells; nanotech-based system for genetic analysis; technology platform offering unique means of DNA isolation as well as effective means of detecting gene variations; and analyst perspectives on speculation surrounding the requirement of HPV vaccine mandate. The alert also delivers a snapshot of strategic partnerships and key patents. http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-9A-00-00 Fri, 2 May 2008 05:25:22 +0100 http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-9A-00-00 Technical Insights Alert This week's issue of GTN Alert profiles articles on a technology platform employing genetic chemistry for cost-effective drug development, spinal muscular atrophy treatment enabled through targeted gene alteration method, RNAi technology utilized for the production of human therapeutic glycoproteins, biomarkers for assessment of cancer therapy outcome, a novel gene sequencing technique enabling researchers to obtain sequence information from single molecules of DNA devoid of gene amplification, novel gene shuffling technique for production of optimized proteins, and an innovative magnetic targeting approach to effectively target tumors.The alert also provides insights into important strategic partnerships as well as important patents. http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-98-00-00 Fri, 25 Apr 2008 04:39:34 +0100 http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-98-00-00 Technical Insights Alert This week's issue of GTN Alert profiles articles on novel therapeutic potential of epigenetic targets, a chemically linked immunogenic peptides on scaffolds technology platform for generating functional antibodies,findings of bacteria that consume both natural as well as synthetic antibiotic compounds, promising therapeutic targets for GERD disease utilizing allosteric modulation mechanism, research findings highlighting mother precursor cells to dopaminergic neurons found in early brain development stages, study findings indicating that molecular changes in the brain are clearly reflected by presence of biomarkers, easy to administer single dose typhoid vaccine and data analysis software for pyrosequencing of DNA. http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-97-00-00 Fri, 18 Apr 2008 04:45:41 +0100 http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-97-00-00 Technical Insights Alert This week's issue of Genetic Technology Alert profiles articles on a technology platform for DNA methylation, herbal dietary supplement to aid in neurological functions, quantification of amyloid beta peptides, molecular mechanism against tuberculosis bacterium, altered polyketides, short hairpin RNAs, a novel recombinant protein production technology, and discovery of viral gene that causes obesity. The alert also provides important patents. http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-96-00-00 Fri, 11 Apr 2008 05:42:24 +0100 http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-96-00-00 Technical Insights Alert This week's issue of Genetic Technology Alert profiles articles on a novel tool for immediate visualization of proteins during the course of protein production in Escherichia coli and protein purification, a novel class of anticancer drugs that primarily disrupt tumor vasculature, angiogenic cell precursor-based technology platform for heart disease treatment, resistance mechanism of Methicillin-resistant Staphylococcus aureus (MRSA) to natural defenses, a breakthrough technology for DNA engineering, discovery of gene behing amyotropic lateral sclerosis (ALS), study that reveals the role of rare gene mutatiosn in schizophrenia and mutated HIV vaccine strategy. The alert also covers important patents and strategic partners. http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-95-00-00 Fri, 4 Apr 2008 03:08:23 +0100 http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-95-00-00 Technical Insights Alert Genentech has chosen an inhibitor of MEK, a member of the MAP pathway, from Exelixis to further develop for treating cancer. Pending final analysis of completed animal toxicology studies NIH and Avicena are ready to start clinical testing of Avicena's lead product candidate, designed to slow the progress of Huntington's disease. VistaGen has formed an alliance with University Health Network to carry out research into advanced techniques to differentiate embryonic stem cells into mature cardiac, liver, and pancreatic beta-islet cells. Centocor and Schering Plough have applied to European regulatory authorities to market golimumab for treating three different autoimmune diseases. http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-94-00-00 Fri, 28 Mar 2008 03:44:17 +0000 http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-94-00-00 Technical Insights Alert Sitris has obtained rights to technology for introducing the NamPRT gene into aging human vascular smooth muscle cells to delay their deterioration. KaloBios is developing a monoclonal antibody against granular macrophage colony-stimulating factor (GM-CSF) to treat inflammation associated with asthma. Cardium's gene therapy prevents reperfusion injury in heart attack patients. Curis looking for a new partner for hedgehog pathway protein agonists for treating stroke after Wyeth discontinued its collaboration. AlphaMed has successfully expressed a glycosylated human version of alpha 1-antitrypsin (AAT) in yeast. Applied Biosystems has brought the cost of sequencing a complete human genome down to $60,000. http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-93-00-00 Fri, 21 Mar 2008 22:37:18 +0000 http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-93-00-00 Technical Insights Alert GammaCan's therapy using immunoglobulins from donors with vitilgo, a skin disorder, shows promise against melanoma in animal experiments. Biovitrum and Syntonix advance clinical testing of a long-acting recombinant factor IX to treat hemophilia B patients. Zevalin, a monoclonal antibody linked to a cell-killing radioactive isotope, combined with CHOP chemotherapy attains a 100% response rate in elderly patients with diffuse large B-cell lymphoma. Research at Dendreon validates the marker it has been using to measure the potency of its Provenge individualized cell therapy before administering it for prostate cancer treatment. Amgen licenses a monoclonal antibody with potential for treating inflammatory disorders and cancer from Kyowa Hakko. http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-92-00-00 Fri, 14 Mar 2008 03:44:39 +0000 http://www.frost.com/prod/servlet/market-service-segment.pag?Src=RSS&segid=D754-00-92-00-00